Semicarbazide hydrochloride → HCID 18958727, compound

HRID 1708427Notes

Reaction equation

HRID 1708427 reaction equation
Cl.[NH2:2][NH:3][C:4]([NH2:6])=[O:5].C[O-].[Na+].[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[C:15]([CH2:17][C:18]#[N:19])=O>C(O)C>[NH2:19][C:18]1[N:3]([C:4]([NH2:6])=[O:5])[N:2]=[C:15]([C:11]2[O:10][CH:14]=[CH:13][CH:12]=2)[CH:17]=1

Participants

5

Reactant 3

HCID 11236Semicarbazide hydrochlorideHCID 1416712-FuroylacetonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 18958727HCID 18958727, compoundYield 70.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 5.5 g of semicarbazide hydrochloride in 100 ml of absolute ethyl alcohol is added 3.0 g of sodium methoxide at room temperature. The reaction mixture is stirred for 30 minutes and 6.0 g of 2-furoyl acetonitrile is added. The reaction mixture is heated at reflux for 1 hour and concentrated in vacuo to a residue. The residue is suspended in water, filtered and dried to give 6.0 g of the desired product as a solid, m.p. 145° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 1 hour
  3. concentrationconcentrated in vacuo to a residue
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-e2f683a49fad4239a7fd767056923d8a
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

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