HCID 12339322, compound → HCID 178441875, compound

HRID 1708430Notes

Reaction equation

HRID 1708430 reaction equation
[NH2:1][C:2]1[N:6]([C:7]([NH2:9])=[O:8])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1>COC(OC)(OC)CCCC>[CH2:3]([C:2]1[NH:1][C:2]2[N:6]([N:5]=[C:4]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:3]=2)[C:7](=[O:8])[N:9]=1)[CH2:4][CH2:10][CH3:11]

Participants

3

Reactant 1

HCID 12339322HCID 12339322, compound

Product 1

HCID 178441875HCID 178441875, compoundYield 150.7%

Reagents, catalysts & solvents 1

HCID 83755Trimethyl orthovalerateSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 4.0 g of the product of Example 2 and 10 ml of trimethylorthovalerate is heated at 130° C. for 1 hour. The reaction mixture is cooled to room temperature and diluted with 400 ml of hexanes. The resulting solid is collected, washed with hexanes and dried to give 4.0 g of the desired product as colorless crystalline solid, m.p. 234° C.

Workup

  1. temperatureThe reaction mixture is cooled to room temperature
  2. customThe resulting solid is collected
  3. washwashed with hexanes
  4. customdried

Sources & evidence

ORD record
ord-b748e360a7dc442499ff2b6edbd4256a
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

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