HCID 18958729, compound → HCID 178441876, compound

HRID 1708431Notes

Reaction equation

HRID 1708431 reaction equation
[NH2:1][C:2]1[N:6]([C:7]([NH2:9])=[O:8])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:3]=1>COC(OC)(OC)CCCC>[CH2:3]([C:2]1[NH:1][C:2]2[N:6]([N:5]=[C:4]([C:10]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[CH:3]=2)[C:7](=[O:8])[N:9]=1)[CH2:4][CH2:10][CH3:11]

Participants

3

Reactant 1

HCID 18958729HCID 18958729, compound

Product 1

HCID 178441876HCID 178441876, compoundYield 123.1%

Reagents, catalysts & solvents 1

HCID 83755Trimethyl orthovalerateSolvent

Procedure

A mixture of 5.0 g of the product of Example 3 and 20 ml of trimethylorthovalerate is heated at reflux for 30 minutes. The reaction mixture is cooled to room temperature and diluted with hexanes. The resulting solid is collected by filtration, washed with hexanes and dried to give 4.0 g of the desired product as a solid, m.p. 238° C.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 30 minutes
  3. filtrationThe resulting solid is collected by filtration
  4. washwashed with hexanes
  5. customdried

Sources & evidence

ORD record
ord-b8cdd21acc5b40b28496236e7f349a2b
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

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