HCID 18958727, compound → HCID 178441877, compound

HRID 1708432Notes

Reaction equation

HRID 1708432 reaction equation
[NH2:1][C:2]1[N:6]([C:7]([NH2:9])=[O:8])[N:5]=[C:4]([C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)[CH:3]=1>COC(OC)(OC)CCCC>[CH2:3]([C:2]1[NH:1][C:2]2[N:6]([N:5]=[C:4]([C:10]3[O:11][CH:12]=[CH:13][CH:14]=3)[CH:3]=2)[C:7](=[O:8])[N:9]=1)[CH2:4][CH2:10][CH3:14]

Participants

3

Reactant 1

HCID 18958727HCID 18958727, compound

Product 1

HCID 178441877HCID 178441877, compoundYield 99.2%

Reagents, catalysts & solvents 1

HCID 83755Trimethyl orthovalerateSolvent

Procedure

A mixture of 3.0 g of the product of Example 1 and 10 ml of trimethylorthovalerate is heated at 130 C. for 30 minutes. The reaction mixture is cooled to room temperature and diluted with hexanes. The resulting colorless solid is collected by filtration, washed with hexanes and dried to give 2.0 g of the desired product as a solid, m.p. 190° C.

Workup

  1. temperatureis heated at 130 C
  2. filtrationThe resulting colorless solid is collected by filtration
  3. washwashed with hexanes
  4. customdried

Sources & evidence

ORD record
ord-8483c59d1dec48ddbc81a748a1bda33d
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

Loading…