HCID 15230387, compound → HCID 178441437, compound

HRID 1708433Notes

Reaction equation

HRID 1708433 reaction equation
[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[N:28](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:27]=[N:26][N:25]=3)=[CH:14][CH:13]=2)[C:9](=[O:48])[N:8]2[N:49]=[C:50]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=3)[CH:51]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]>CC(C)=O>[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:25][N:26]=[N:27][N:28]=3)=[CH:16][CH:17]=2)[C:9](=[O:48])[N:8]2[N:49]=[C:50]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=3)[CH:51]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 15230387HCID 15230387, compound

Product 1

HCID 178441437HCID 178441437, compoundYield 64.8%

Reagents, catalysts & solvents 1

HCID 180AcetoneCatalyst

Procedure

A solution of 800 mg of the product of Example 7 in 100 ml of acetone containing 3 drops of 5% HC1 is refluxed for 16 hours. The reaction mixture is concentrated in vacuo to a residue which is purified by column chromatography on silica gel by elution with 70% ethyl acetate-hexanes to give 350 mg of the desired product as a solid. M+H 503

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo to a residue which
  2. customis purified by column chromatography on silica gel by elution with 70% ethyl acetate-hexanes

Sources & evidence

ORD record
ord-ca04fcded7d9465b97b27087ccda9cc8
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

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