Bromine → HCID 178441878, compound

HRID 1708437Notes

Reaction equation

HRID 1708437 reaction equation
[CH2:1]([C:5]1[NH:6][C:7]2[N:8]([N:12]=[CH:13][CH:14]=2)[C:9](=[O:11])[N:10]=1)[CH2:2][CH2:3][CH3:4].[Br:15]Br>C(Cl)(Cl)Cl.C(O)(=O)C>[Br:15][C:14]1[CH:13]=[N:12][N:8]2[C:9](=[O:11])[N:10]=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[NH:6][C:7]=12

Participants

4

Reactant 2

HCID 24408BromineHCID 178441879HCID 178441879, compound

Product 1

HCID 178441878HCID 178441878, compound

Reagents, catalysts & solvents 1

HCID 21584526Acetic acid chloroformSolvent

Procedure

To a solution of 4.0 g of the product of Example 15 in 25 ml of 3:1 chloroform-acetic acid is added 1.5 ml of bromine. The reaction mixture is stirred at room temperature for 4 hours. The chloroform is removed in vacuo and the residue diluted with ice water. The resulting solid is collected, washed with water and dried to give 3.5 g of the desired product as a brown solid, m.p. 188° C.

Workup

  1. customThe chloroform is removed in vacuo
  2. additionthe residue diluted with ice water
  3. customThe resulting solid is collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-1f08637aa3994084b909259a3753bdb8
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

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