反应详情

To a solution of 0.500 g of 2-Butyl-6-ethenyl-3-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-4(3H)-quinazolinone in 25 ml of toluene is added 0.201 g of 2,3,4,5-tetrahydro-6-methyl-pyridine 1-oxide and the reaction mixture heated at reflux for 12 hours. The reaction mixture is cooled and concentrated in vacuo to a residue which is purified by chromatography on silica gel by elution with 1:2 ethyl acetate-hexanes to give 0.108 g of the desired product.

1. temperaturethe reaction mixture heated
2. temperatureat reflux for 12 hours
3. temperatureThe reaction mixture is cooled
4. concentrationconcentrated in vacuo to a residue which
5. customis purified by chromatography on silica gel by elution with 1:2 ethyl acetate-hexanes