Sodium Hydroxide → HCID 14674838, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-cyclohexyl-2-[4-(quinolin-2-yl-methoxy)phenyl]propionic acid methyl ester (650 mg; 1.6 mmol) in methanol (20 ml) was added 1N sodium hydroxide (3 ml) and the mixture was stirred at 50° C. for 10 h. The methanol was removed in vacuo, to the residue was added 10 ml of water and the resulting mixture was acidified to pH 4. The precipitated solid was filtered, washed with water and dried in vacuo to provide 550 mg of 3-cyclohexyl-2-[4-(quinolin-2-yl-methoxy)phenyl]propionic acid, mp. 148°-150° C.

Provenance & Evidence