Ammonia → 2-Cycloheptyl-2-[4-(quinolin-2-yl-methoxy)phenyl]acetic acid N-hydroxy-N-methoxy-amide

Participants

Reaction Steps

The desired material was prepared according to the procedures described in Example 4 substituting 2-cycloheptyl-2-[4-(quinolin-2yl-methoxy)phenyl]acetic acid, prepared according to the procedure described in U.S. Pat. No. 4970215, for 2-cyclopentyl-2-[4-(quinolin-2-yl-methoxy)phenyl]acetic acid and Example 6 substituting 2-cycloheptyl-2-[4-(quinolin-2-yl-methoxy)phenyl]-acetic acid for {[1-(3-[2-naphthylmethoxy]-phenyl)4-phenylbutyl]oximino}acetic acid. 1H NMR (DMSO-d6, 300 MHz) δ 0.93 (m, 1H), 1.22 (m, 3H), 1.48 (m, 8H), 2.1 (m, 1H), 3.02 (s, 3H), 3.94 (d, J=7Hz, 1H), 5.33 (s, 2H), 7.0 (d, J=7Hz, 2H), 7.23 (d, J =7Hz, 2H), 7.62 (d-t, J=8Hz, 2Hz, 1H), 7.68 (d, J=8Hz, 1H), 7.8 (d-t, J=8Hz, 2Hz, 1H), 8.0 (t, J=8Hz, 2H), 8.42 (d, J=8Hz, 1H), 9.82 (s, 1H). IR (CDCl3): 3520, 1610 cm-1. MS (DCI/NH3) m/e 419 (M+H)+.

Provenance & Evidence