反应详情

The desired material was prepared according to the procedures described in Example 5 substituting 2-methoxy-2-[4-(quinolin-2-yl-methoxy)phenyl]acetic acid for {[1-(3-[2-naphthylmethoxy]phenyl)-4-phenylbutyl]oximino}acetic acid. 1H NMR (DMSO-d6, 300 MHz) δ 3.06 (s, 3H), 3.21 (s, 3H), 5.24 (s, 1H), 5.37 (s, 2H), 7.03 (d, J=7Hz, 2H), 7.3 (d, J=7Hz, 2H), 7.63 (m, 1H), 7.68 (d, J=8Hz, 1H), 7.8 (dt, J=8Hz, 2Hz, 1H), 8.0 (m, 2H), 8.42 (d, J=8Hz, 1H), 9.9 (s, 1H). IR (CDCl3): 3640, 3500, 3220, 1640, 1610 cm-1. MS (DCI/NH3) m/e 353 (M+H)+. Analysis calcd for C20H20N2O4 : C, 68.17; H, 5.72; N, 7.95. Found: C, 67.32; H, 5.61; N, 7.94.