Ammonia → 2-Methoxy-2-[4-(pyrid-2-yl-methoxy)phenyl]acetic acid N-hydroxy-N-methyl-amide

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Reaction Steps

The desired material was prepared according to the procedures described in Example 5 substituting 2-methoxy-2-[4-(pyrid-2-ylmethoxy)phenyl]acetic acid for {[1-(3-[2-naphthylmethoxy]phenyl)-4-phenylbutyl]oximino}acetic acid. 1H NMR (DMSO-d6, 300 MHz) δ 3.07 (s, 3H), 3.12 (s, 3H), 5.18 (s, 2H), 5.23 (s, 1H), 7.0 (d, J=7Hz, 2H), 7.3 (d, J=7Hz, 2H), 7.34 (m, 1H), 7.5 (d, J=7Hz, 1H), 7.83 (dt, J=7Hz, 2Hz, 1H), 8.04 (m, 1H), 9.9 (bs, 1H). IR (CDCl3): 3620, 3500, 1640, 1610 cm-1. MS (DCI/NH3) m/e 301 (M+H)+. Analysis calcd for C16H18N2O4 ·0.5 H2O: C, 61.73; H, 6.15; N, 9.04. Found: C, 61.96; H, 5.77; N, 8.86. (In some examples O-acylated products were isolated.)

Provenance & Evidence