Ammonia → N-Methyl-O-{3-cyclohexyl-2-[4-(pyrid-2-yl-methoxy)phenyl]propionyl}-hydroxylamine

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Reaction Steps

The above material was obtained as a side product of Example 11. 1H NMR (DMSO-d6, 300 MHz) δ 0.9 (m, 2H), 1.1 (m, 4H), 1.63 (m, 6H), 1.81 (m, 1H), 2.6 (d, J=6Hz, 3H), 3.65 (t, J=7Hz, 1H), 5.17 (s, 2H), 7.0 (d, J=7Hz, 2H), 7.23 (d, J=7Hz, 2H), 7.35 (m, 1H), 7.5 (d, J=8Hz, 1H), 7.83 (dt, J=8Hz, 2Hz, 1H), 7.9 (q, J=6Hz, 1H), 8.6 (m, 1H). IR (CDCl3): 3245, 1735, 1610 cm-1. MS (DCI/NH3) m/e 369 (M+H)+. The above material was also obtained according to the procedures described in Example 17 substituting N-methylhydroxyl-amine for N,N-dimethylhydroxylamine.

Provenance & Evidence