HCID 178430897, compound → HCID 178430896, compound

HRID 1708515Notes

Reaction equation

HRID 1708515 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2C=NC=N2)=[N:4][C:5](=[O:8])[NH:6][CH:7]=1>N>[CH3:1][C:2]1[C:3]([NH2:9])=[N:4][C:5](=[O:8])[NH:6][CH:7]=1

Participants

3

Reactant 1

HCID 178430897HCID 178430897, compound

Product 1

HCID 178430896HCID 178430896, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

1.06 g (6 mmol) of 5-methyl-4-(1,2,4-triazol-1-yl)-pyrimidin-2(1H)-one are dissolved in 30 ml of concentrated aqueous ammonia and stirred for 3 hours at reflux temperature. The cooled solution is evaporated to dryness, the residue is dissolved in hot water, the solution is cooled and three times the amount of acetone are added. The precipitate is filtered off by suction and is dried in vacuo. 0.73 g (97.3% of theory) of 5-methyl-cytosine is obtained as a colorless powder with melting point 271°-274° C.

Workup

  1. temperatureat reflux temperature
  2. customThe cooled solution is evaporated to dryness
  3. dissolutionthe residue is dissolved in hot water
  4. temperaturethe solution is cooled
  5. additionthree times the amount of acetone are added
  6. filtrationThe precipitate is filtered off by suction
  7. customis dried in vacuo

Sources & evidence

ORD record
ord-e4bbbcfa03ac4c1b9f5ec7646170f6e8
Source dataset
uspto-grants-1994_10
Patent number
US05359067

Reaction notes

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