Methyl iodide → HCID 18994397, compound

HRID 1708526Notes

Reaction equation

[OH:1][C:2]1([C:8]2[S:9][C:10]([S:13][C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=3)=[CH:11][CH:12]=2)[CH2:6][CH2:5][O:4][CH:3]1[CH3:7].[CH3:24]I>>[CH3:24][O:1][C:2]1([C:8]2[S:9][C:10]([S:13][C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=3)=[CH:11][CH:12]=2)[CH2:6][CH2:5][O:4][CH:3]1[CH3:7]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 18994388HCID 18994388, compound

Product 1

HCID 18994397HCID 18994397, compoundYield 75%

Procedure

Using the procedure described in Example 1, (2RS,3RS)-3-hydroxy-2-methyl-3-[5-(naphth-2-ylthio)thien-2-yl]tetrahydrofuran was reacted with methyl iodide to give (2RS,3RS)-3-methoxy-2-methyl-3-[5- (naphth-2-ylthio)thien-2-yl]tetrahydrofuran in 75% yield as an oil.

Sources & evidence

ORD record: ord-a3b7bb0436d0460e90947b534d52bb97
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05359063

Reaction notes

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