HCID 20083118, compound → HCID 20083112, compound

Participants

Reaction Steps

Ethyl 1-(N-tert-butoxycarbonyl-N-methylamino)-5,6,7,8-tetrafluoro -1,4-dihydro-4-oxoquinoline-3-carboxylate (4.2 g) was dissolved in ethyl acetate (30 ml),. 4N hydrochloric acid-dioxane solution (40 ml) was added thereto with ice-cooling and stirred overnight at room temperature, and the solvent was removed by distillation. The residue was dissolved in chloroform (100 ml), and 10% sodium carbonate aqueous solution (50 ml) was added thereto and stirred for 30 minutes at room temperature. The organic layer was separated out and dried over magnesium sulfate, and the solvent was removed by distillation. The crystals were dispersed in ether and filtered out to obtain ethyl 1-methylamino-5,6,7,8-tetrafluoro -1,4-dihydro-4-oxoquinoline-3-carboxylate (2.9 g).

Provenance & Evidence