Potassium Fluoride → Ethyl 6,7,8-trifluoro-1-(methylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Reaction Steps

A mixture of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-(2-tert-butoxycarbonyl-2-methylhydrazino)acrylate (2.00 g) and potassium fluoride (0.31 g) in dimethylformamide(5 ml) was heated at 60°~65° C. for one hour, and refluxed for 5 hours. The mixture was poured into ice-water (60 ml) to give a solid. The solid was collected by filtration and dried over phosphorus pentaoxide under reduced pressure to give ethyl 6,7,8-trifluoro-1-methylamino-1,4-dihydro-4-oxoquinoline-3-carboxylate (1.25 g).

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