Malic Acid → HCID 86748212, compound

HRID 1708687Notes

Reaction equation

HRID 1708687 reaction equation
C(Cl)(=O)C.[C:5]([OH:13])(=[O:12])[CH:6]([CH2:8][C:9]([OH:11])=[O:10])[OH:7]>>[C:9]([OH:11])(=[O:10])[CH3:8].[C:5]1(=[O:12])[O:13][C:9](=[O:11])[CH2:8][CH:6]1[OH:7]

Participants

3

Reactant 2

HCID 525Malic AcidHCID 6367Acetyl chloride2×

Product 1

HCID 86748212HCID 86748212, compound

Procedure

Three equivalents of acetyl chloride were added dropwise in a flask to one equivalent of malic acid while keeping the temperature below 0° C. After the acetyl chloride was added, the mixture was stirred at room temperature overnight. Excess acetyl chloride and acetic acid were then distilled under a water pump at room temperature to provide malic anhydride acetate.

Workup

  1. customthe temperature below 0° C
  2. distillationExcess acetyl chloride and acetic acid were then distilled under a water pump at room temperature

Sources & evidence

ORD record
ord-2e44a61ebf63467184aa2870ced09820
Source dataset
uspto-grants-1994_10
Patent number
US05359128

Reaction notes

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