HuagongsheHuagongshe Chemistry Print Report · For research reference only
20-(5,5-dimethyl-1,3-dioxan-2-yl)-1alpha,2alpha-epoxy-7alpha-(N-methylcarbamoyloxy)pregn-5-en3beta-ol → 1alpha,2alpha-epoxy-3beta-hydroxy-7alpha-(N-methylcarbamoyloxy)pregn-5-ene-20-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1alpha,2alpha-epoxy-7alpha-(N-methylcarbamoyloxy)pregn-5-en3beta-ol | HCID 57055127 | — |
| Reactant | 20-(5,5-Dimethyl-1,3-dioxan-2-yl)-1alpha,2alpha-epoxypregn-5-ene-3beta,7alpha-diol | HCID 86745808 | — |
| Product | 1alpha,2alpha-epoxy-3beta-hydroxy-7alpha-(N-methylcarbamoyloxy)pregn-5-ene-20-carbaldehyde | HCID 88463721 | 62.7% |
Reaction Steps
The procedure of Example 36 was repeated except that 2.5 mg (0. 005 mmole) of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α,2α-epoxy-7α-(N-methylcarbamoyloxy)pregn-5-en-3β-ol was used in lieu of 2.2 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α,2α-epoxypregn-5-ene-3β,7α-diol to give 1.3 mg of 1α,2α-epoxy-3β-hydroxy-7α-(N-methylcarbamoyloxy)pregn-5-ene-20-carbaldehyde (yield: 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05359055 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-63be71f0a7f34e9f974196e566c0e8c5 |
| Source note | uspto-grants-1994_10 |