HuagongsheHuagongshe Chemistry Print Report · For research reference only
20-(5,5-Dimethyl-1,3-dioxan-2-yl)-1alpha, 2alpha-epoxy-7alpha-hydroxypregna-5-en-3beta-yl acetate → 1alpha,2alpha-Epoxy-21,21-dimethoxy-7alpha-methoxycarbonyloxy-20-methylpregn-5-en-3beta-yl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 20-(5,5-Dimethyl-1,3-dioxan-2-yl)-1alpha, 2alpha-epoxy-7alpha-hydroxypregna-5-en-3beta-yl acetate | HCID 86745802 | — |
| Reactant | 1alpha,2alpha-Epoxy-7alpha-hydroxy-21,21-dimethoxy-20-methylpregn-5-en-3beta-yl acetate | HCID 86745824 | — |
| Product | 1alpha,2alpha-Epoxy-21,21-dimethoxy-7alpha-methoxycarbonyloxy-20-methylpregn-5-en-3beta-yl acetate | HCID 86745823 | 77% |
Reaction Steps
The procedure of Example 12 was repeated except that 45.0 mg (0.1 mmole) of 1α,2α-epoxy-7α-hydroxy-21,21-dimethoxy-20-methylpregn-5-en-3β-yl acetate was used in lieu of 49.0 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α,2α-epoxy-7α-hydroxypregna-5-en-3β-yl acetate to give 39.0 mg of 1α,2α-epoxy-21,21-dimethoxy-7α-methoxycarbonyloxy-20-methylpregn-5-en-3β-yl acetate (yield: 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05359055 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-de75c6b7fdd544b2abae1fec30328b1e |
| Source note | uspto-grants-1994_10 |