HuagongsheHuagongshe Chemistry Print Report · For research reference only
20-(5,5-Dimethyl-1,3-dioxan-2-yl)-1alpha,2alpha-epoxypregna-5,7-dien-3beta-ol → 21,21-Dimethoxy-20-methylpregna-5,7-diene-1alpha,3betadiol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 20-(5,5-Dimethyl-1,3-dioxan-2-yl)-1alpha,2alpha-epoxypregna-5,7-dien-3beta-ol | HCID 22843922 | — |
| Reactant | 1alpha,2alpha-Epoxy-21,21-dimethoxy-20-methylpregna-5,7-dien-3beta-ol | HCID 86745826 | — |
| Product | 21,21-Dimethoxy-20-methylpregna-5,7-diene-1alpha,3betadiol | HCID 57189343 | 76.1% |
Reaction Steps
The procedure of Example 24 was repeated except that 3.4 mg (0. 00887 mmole) of 1α,2α-epoxy-21,21-dimethoxy-20-methylpregna-5,7-dien-3β-ol was used in lieu of 3.8 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)-1α,2α -epoxypregna-5,7-dien-3β-ol to give 2.6 mg of 21,21-dimethoxy-20-methylpregna-5,7-diene-1α,3β-diol (yield: ca. 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05359055 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-177e3a313e0f4d8b916189428a014914 |
| Source note | uspto-grants-1994_10 |