Chloroacetic Acid → 20-(1,3-Dioxolan-2-yl)-3beta-acetoxy-1alpha-benzoyloxy-7alpha-(methoxycarbonyl)oxypregn-5-ene

Participants

Reaction Conditions

Reaction Steps

In 10 ml of dimethyl carbonate was dissolved 350 mg of 20-(1,3-dioxolan-2-yl)-3β-acetoxy-1α-benzoyloxypregn-6-en-5α-ol, followed by addition of 0.1 ml of monochloroacetic acid. The mixture was stirred in an atmosphere of argon gas under heating at a temperature of 100° C. for 10 hours. The reaction mixture was then worked up in the same manner as Example 132 to give 100 mg of 20-(1,3-dioxolan- 2-yl)-3β-acetoxy-1α-benzoyloxy-7α-(methoxycarbonyl)oxypregn-5-ene showing the following physical properties.

Provenance & Evidence