HuagongsheHuagongshe Chemistry Print Report · For research reference only
1alpha,3beta-Bis(methoxycarbonyloxy)pregna-5,7-diene-20-carbaldehyde → 21,21-Dimethoxy-20-methylpregna-5,7-diene-1alpha,3betadiol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1alpha,3beta-Bis(methoxycarbonyloxy)pregna-5,7-diene-20-carbaldehyde | HCID 54367523 | — |
| Reactant | 3beta-benzoyloxy-21,21-dimethoxy-20-methyl-1alpha-(N-methylcarbamoyl)oxypregna-5,7-diene | HCID 67852980 | — |
| Product | 21,21-Dimethoxy-20-methylpregna-5,7-diene-1alpha,3betadiol | HCID 57189343 | 91.8% |
Reaction Steps
The reaction and workup procedures of Example 164 were repeated except that 100 mg of 3β-benzoyloxy-21,21-dimethoxy-20-methyl-1α-(N-methylcarbamoyl)oxypregna-5,7-diene was used in lieu of 100 mg of 1α,3β-bis(methoxycarbonyloxy)pregna-5,7-diene-20-carbaldehyde to give 65 mg of 21,21-dimethoxy-20-methylpregna-5,7-diene-1α,3β-diol showing the following physical properties.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05359055 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-f5bb37c6a4af4fd2bd56208811bc02aa |
| Source note | uspto-grants-1994_10 |