Ammonium Carbonate → 1-methyl-1H-pyrazole-3-sulfonamide

HRID 1708842Notes

Reaction equation

HRID 1708842 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[N:3]1.C(=O)([O-])[O-].[NH4+:15].[NH4+]>C(Cl)(Cl)Cl>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([S:7]([NH2:15])(=[O:9])=[O:8])=[N:3]1

Participants

4

Reactant 2

HCID 517111Ammonium CarbonateHCID 134744661-Methyl-1H-pyrazole-3-sulfonyl chloride

Product 1

HCID 148356431-methyl-1H-pyrazole-3-sulfonamide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture containing chloroform (100 ml), 13.6 g of 1-methylpyrazole-3-sulfonyl chloride and 13.6 g ammonium carbonate was heated to reflux for six hours, cooled, filtered and the solid was washed with water. The water-insoluble solid which was recrystallized from 50% ethanol-water melted at 149°-151° and showed absorption peaks in the infrared at 3100 and 3200 cm-1, consistent for the NH2 in the desired product.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for six hours
  3. temperaturecooled
  4. filtrationfiltered
  5. washthe solid was washed with water
  6. customThe water-insoluble solid which was recrystallized from 50% ethanol-water melted at 149°-151°
  7. customabsorption peaks in the

Sources & evidence

ORD record
ord-d5421b7b4b3149f29a402a8836243c81
Source dataset
uspto-grants-1990_08
Patent number
US04946496

Reaction notes

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