Pyridine → HCID 131716492, compound

HRID 1708882Notes

Reaction equation

HRID 1708882 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@H:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[CH3:16][S:17][C:18](SC)=[N:19]C#N.[N:24]1C=CC=C[CH:25]=1>>[C:25]([N:1]([C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@H:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1)[C:18](=[NH:19])[S:17][CH3:16])#[N:24]

Participants

4

Reactant 3

HCID 1049PyridineHCID 66289Dimethyl N-cyanodithioiminocarbonateHCID 10465484(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Product 1

HCID 131716492HCID 131716492, compound

Procedure

A stirred mixture of (R)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (4 g) and dimethyl cyanodithioiminocarbonate in pyridine is heated to afford (R)-6-(4-(N-cyano-S-methylisothioureido)phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone.

Workup

  1. temperatureis heated

Sources & evidence

ORD record
ord-3e0eb3e35819453dbef359a3d99cf4e3
Source dataset
uspto-grants-1990_08
Patent number
US04946842

Reaction notes

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