Pyridine → HCID 178461474, compound

HRID 1708883Notes

Reaction equation

C([N:3]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C@H:15]([CH3:21])[CH2:16][C:17](=[O:20])[NH:18][N:19]=2)=[CH:10][CH:9]=1)[C:4](=[NH:7])SC)#N.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[N:30]1C=CC=C[CH:31]=1>>[CH2:22]([NH:29][C:4](=[N:7][C:31]#[N:30])[NH:3][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[C@H:15]([CH3:21])[CH2:16][C:17](=[O:20])[NH:18][N:19]=2)=[CH:12][CH:13]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

Reactant 3

HCID 1049Pyridine

HCID 7504Benzylamine

HCID 131716492HCID 131716492, compound

Product 1

HCID 178461474HCID 178461474, compound

Procedure

A stirred mixture of (R)-6-(4-(N-cyano-S-methylisothioureido)phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and benzylamine in pyridine is heated to afford (R)-6-[4-(N3 -benzyl-N2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.

Workup

temperatureis heated

Sources & evidence

ORD record: ord-c9da8f57601d44e69b7bc2f0dfc75692
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04946842

Reaction notes

Loading…