Sodium Carbonate → HCID 54145444, compound

HRID 1708912Notes

Reaction equation

HRID 1708912 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[C:11]([NH:12][CH2:13][CH2:14][O:15][CH2:16][CH3:17])=[CH:10][CH:9]=[CH:8][N:7]=1)=[O:4].[C:18]1([CH2:24][N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(=O)([O-])[O-].[Na+].[Na+]>CC1C=CC=CC=1>[CH2:16]([O:15][CH2:14][CH2:13][NH:12][C:11]1[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:28]2[CH2:29][CH2:30][N:25]([CH2:24][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:26][CH2:27]2)=[N:7][CH:8]=[CH:9][CH:10]=1)[CH3:17]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 759941-BenzylpiperazineHCID 19911565HCID 19911565, compound

Product 1

HCID 54145444HCID 54145444, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3.62 parts of 2-chloro-N-[3-[(2-ethoxyethyl)amino]2-pyridinyl]acetamide, 10.6 parts of 1-(phenylmethyl)piperazine, 6.4 parts of sodium carbonate and 90 parts of methylbenzene was stirred for 20 hours at 80° C. The reaction mixture was evaporated and the residue was taken up in water. The product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 7.9 parts (100%) of N-[3-[(2-ethoxyethyl)amino]-2-pyridinyl]-4-(phenylmethyl)-1-piperazineacetamide as a residue (int. 25).

Workup

  1. customThe reaction mixture was evaporated
  2. extractionThe product was extracted with dichloromethane
  3. customThe extract was dried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-695be7f28e994ca1ab23fb185f12b247
Source dataset
uspto-grants-1990_08
Patent number
US04946843

Reaction notes

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