Nitric Acid → 2,6-Dichloro-3-nitrobenzamide

Participants

Reaction Steps

A solution of 12 g of fuming HNO3 (d=1.52) in 11 ml of concentrated H2SO4 is added at room temperature over a period of 30 minutes to a solution of 30.4 g of 2,6-dichlorobenzoic acid amide in 60 ml of concentrated H2SO4 (d=1.83). After stirring for 2 hours at room temperature, the reaction mixture is added to ice/H2O and adjusted to a pH of ~ 6 with 30% NaOH and the precipitating crystals are isolated by filtration, affording 28.7 g of 2,6-dichloro-3-nitrobenzoic acid amide (m.p. 163°-165° C.).

Provenance & Evidence