反应详情

To N-(2-(4-methylphenyl)-4-thiazolyl)-1H-tetrazole-5-carboxamide (Ia-5) (100 mg, 0.35 mmol) dissolved in dry methanol (10 ml) was added dropwise 2-aminoethanol (0.23 ml, 0.39 mmol) and the mixture was allowed to react at room temperature for 30 minutes. The solvent was distilled off from the reaction mixture. The residue was crystallized by adding dry ether, filtered with suction and dried to give pale yellow solids of N-(2-(4-methylphenyl)-4-thiazolyl)-1H-tetrazole-5-carboxamide 2-aminoethanol salt (Ia-5") (112 mg, yield 92%), m.p. 172°-175° C.

1. customto react at room temperature for 30 minutes
2. distillationThe solvent was distilled off from the reaction mixture
3. customThe residue was crystallized
4. additionby adding dry ether
5. filtrationfiltered with suction
6. customdried