反应详情

An autoclave was charged with 7.5 g of 2-(benzylmethylamino)-3,7,11-trimethyl-3,7-dodecanediol, 0.75 g of palladium-on-carbon and 30 ml of ethanol, and the reaction was conducted at 40° C. under hydrogen pressure (10 atm). After completion of the reaction, the ethanol was distilled off and the residue was subjected to silica gel column chromatography (elution with 95% ethanol-5% triethylamine) to give 3.6 g of 2-(methylamino)-3,7,11-trimethyl-3,7-dodecanediol [Compound (70)]. Yield 65%.

1. customwas conducted at 40° C. under hydrogen
2. customAfter completion of the reaction
3. distillationthe ethanol was distilled off
4. washthe residue was subjected to silica gel column chromatography (elution with 95% ethanol-5% triethylamine)