5-(Chloromethyl)-1,2,3-trimethoxybenzene → 1-(3,4,5-Trimethoxybenzyl)-1-(2-thienyl)propyl isocyanide

HRID 1708968Notes

Reaction equation

HRID 1708968 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([N+:9]#[C-:10])[CH2:7][CH3:8].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[C:19]([O:23][CH3:24])[C:20]=1[O:21][CH3:22])[CH2:16]Cl>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[C:19]([O:23][CH3:24])[C:20]=1[O:21][CH3:22])[CH2:16][C:6]([N+:9]#[C-:10])([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzeneHCID 152885881-(2-Thienyl)propyl isocyanide

Product 1

HCID 230390111-(3,4,5-Trimethoxybenzyl)-1-(2-thienyl)propyl isocyanideYield 67.5%

Procedure

2.5 g of 1-(2-thienyl)propyl isocyanide and 4.4 g of 3,4,5-trimethoxybenzyl chloride are treated in the same manner as described in Example 1-(1) to give 3.7 g of 1-(3,4,5-trimethoxybenzyl)-1-(2-thienyl)propyl isocyanide as a colorless oil. yield; 67.5%

Sources & evidence

ORD record
ord-e42ac0c041404f05a6a9d1401b2b93d8
Source dataset
uspto-grants-1990_08
Patent number
US04946862

Reaction notes

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