Acetic Acid → HCID 23039052, compound

Participants

Reaction Steps

2 g of 6-hydroxy-N,N-diethyl-1-indan-methylamine and 1.5 g of propylisocyanate were refluxed in 25 ml of dry toluene for 16 hours. The reaction mixture was poured into 100 ml of 0.1M acetic acid, and the organic phase was separated. The water phase was made alkaline with dil. NH4OH and extracted with 2×50 ml diethyl ether. The combined organic phases were dried (MgSO4) and the solvent evaporated. The residue was purified by column chromatography yielding 1.1 g of the title compound as an oil.

Provenance & Evidence