Pyridine → HCID 11019386, compound

HRID 1709015Notes

Reaction equation

HRID 1709015 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([CH3:3])=[CH2:2].N1C=CC=CC=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>CCOCC>[C:17]([O:10][C:6]1[CH:5]=[C:4]([C:1]([CH3:3])=[CH2:2])[CH:9]=[CH:8][CH:7]=1)(=[O:19])[CH3:18]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 135361543-(Prop-1-en-2-yl)phenol

Product 1

HCID 11019386HCID 11019386, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

250 g (1.86 mol) m-isopropenylphenol and 15 mL (0.19 mol) pyridine were placed in a four-neck flask equipped with a stirrer, reflux condenser, addition funnel, and thermometer. While stirring with cooling on a water bath, 200 mL (2.12 mol) acetic anhydride was dripped in. The reaction mixture was then diluted with ether and washed with water to neutrality. Drying and distillation afforded 310 g (1.76 mol) of the target material. The yield was 94%. The properties of this product are reported below.

Workup

  1. customequipped with a stirrer
  2. temperaturereflux
  3. additioncondenser, addition funnel
  4. temperaturewith cooling on a water bath
  5. washwashed with water to neutrality
  6. customDrying
  7. distillationdistillation

Sources & evidence

ORD record
ord-8c679ee7deec4d43983ff31d2ad7c75a
Source dataset
uspto-grants-1990_08
Patent number
US04946921

Reaction notes

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