HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 7-Chloro-1,2-benzisothiazole-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | HCID 13686308 | HCID 13686308 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 7-Chloro-1,2-benzisothiazole-1,1-dioxide | HCID 13686309 | 69.9% |
Reaction Steps
A solution of 37 g of 2-t-butyl-3-hydroxy-7-chloro-2,3-dihydro-1,2-benzoisothiazole-1,1-dioxide and 0.2 g of tosic acid in 370 mls of benzene was refluxed through a Dean-Stark water separator for 16 hours, cooled in ice and filtered to give 18.9 g of the title compound as colorless crystals, m.p. 162°-164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04948416 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-7182f13f08984175b00f21292b7204c2 |
| Source note | uspto-grants-1990_08 |