Potassium Carbonate → (6α)-17,21-Dihydroxy-6-Methylpregna-1,4,9(11)-triene-3,20-dione

Participants

Reaction Steps

A 13.58 g sample of 21-acetoxy-17α-hydroxy-6α-methylpregna-1,4,9-(11)-triene-3,20-dione in methanol (850 ml) was hydrolyzed with 10% potassium carbonate (34 ml). The reaction mixture was acidified, diluted with water and concentrated to give a gummy precipitate which was dissolved in ethyl acetate. The extract was washed with water and brine, then dried over sodium sulfate and evaporated. Crystallization of the residue from acetone-hexane gave the title compound Example 2(a), m.p. 204°-206° C.; one spot by TLC (10% CH3OH--CHCl3).

Provenance & Evidence