Ammonium Chloride → HCID 14822850, compound

Participants

Reaction Steps

80 ml of a 2M MeLi-LiBr solution in ethyl ether was added dropwise, under nitrogen stream, to a solution of 17.7 g of (7-chloro-2,3-dihydro-2-methyl-1,4-benzodioxin-2-yl)carboxylic acid (prepared as described in Example 3) dissolved in 420 ml of anhydrous ethyl ether. The reaction mixture was refluxed for 1 hour, then poured into 200 ml of a NH4Cl saturated solution. The separated ether phase was washed with NaHCO3 and water, then dried. Solvent was removed under vacuum. After distillation, 2-acetyl-7-chloro-2,3-dihydro-2-methyl-1,4-benzodioxin (b.p. 168°-173° C. 0.6 mm Hg) was obtained.

Provenance & Evidence