HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Fluorobenzoyl)piperidine → HCID 14392397, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Fluorobenzoyl)piperidine | HCID 2724440 | — |
| Reactant | 2-[2-(Oxiran-2-yl)ethyl]hexahydro-1H-isoindole-1,3(2H)-dione | HCID 14441495 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 14392397 | HCID 14392397 | 39.8% |
Reaction Steps
A mixture of N-(3,4-epoxybutyl)cyclohexane-1,2-dicarboximide (3 g), 4-(4-fluorobenzoyl)piperidine (3.23 g) and n-butanol (62 ml) was refluxed for 6 hours, followed by evaporation of n-butanol under reduced pressure. The residue was purified by silica gel column chromatography to give the objective compound (2.3 g). Yield, 38.2%. M.P., 121°-122° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04948799 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-539381fee36e45bc8f429d03d6603e5f |
| Source note | uspto-grants-1990_08 |