Benzoyl chloride → 1-Benzoyl-5-(3-methylbutoxy)pyrrolidin-2-one

Participants

Reaction Steps

12.8 cm3 of a 1.5M solution of butyllithium in hexane is added at -70° C. to a solution of 3.3 g of 5-(3-methylbutoxy) pyrrolidin-2-one in 140 cm3 of tetrahydrofuran. The mixture is maintained for 20 minutes at this temperature, then a solution of 2.7 g of benzoyl chloride in 20 cm3 of tetrahydrofuran is added. The solution is returned to ambient temperature, concentrated to dryness under reduced pressure and chromatographed on silica (eluent: hexane-ethyl acetate 7-3) 3.5 g of expected product is obtained.

Provenance & Evidence