HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 14835900, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5H-Benzo(4,5)cyclohepta(1,2-b)pyridin-5-ol, 10,11-dihydro- | HCID 28824 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 14835900 | HCID 14835900 | — |
Reaction Steps
21.1 g of 5-hydroxy-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine was suspended in 100 ml of methylene chloride. To the suspension was added 35.7 g of thionyl chloride with water-cooling. The resulting mixture was stirred for 1 hour at room temperature. The solvent was removed by distillation under reduced pressure to obtain crystals of 5-chloro-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine hydrochloride. The crystals were suspended in 100 ml of methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04948796 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-1f16ab46d06c4285b14c3185c5523486 |
| Source note | uspto-grants-1990_08 |