HCID 14835770, compound → HCID 14835771, compound

Participants

Reaction Conditions

Reaction Steps

7.0 g of 3-nitro-5-[4-{(E)-3-(3-triphenylmethylaminophenyl)allyl}piperazin-1-yl]-10,11-dihydro-5H-dibenzo[a,d]cycloheptene was dissolved in 20 ml of acetic acid and 20 ml of methanol. The solution was stirred for 2 hours at 40° C. The solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 ml of ethyl acetate. The solution was washed with a saturated aqueous sodium hydrogen-carbonate solution, water and a saturated aqueous sodium chloride solution in this order and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure. The residue was purified by a column chromatography (eluant: chloroform/ethanol=50/1) to obtain 3.77 g of light yellow solid 3-nitro-5-[4-{(E)-3-(3-aminophenyl)allyl}-piperazin-1-yl]-10,11-dihydro-5H-dibenzo[a,d]cycloheptene.

Provenance & Evidence