Triethylamine → HCID 14835772, compound

Participants

Reaction Steps

1.01 g of (E)-3-(1-methyl-6-indolyl)acrylic acid was suspended in 20 ml of methylene chloride. 560 mg of triethylamine was added thereto. To the mixture was dropwise added 570 mg of ethyl chlorocarbonate at -30° to -20° C. The mixture was stirred for 1 hour at the same temperature. To the reaction mixture was added 1.73 g of 5-(piperazin-1-yl)-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine dihydrate. The mixture was stirred for 1 hour at room temperature. To the reaction mixture was added 20 ml of water. The organic layer was separated, washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure. The residue was purified by a column chromatography (eluant: n-hexane/acetone=5/1) to obtain 1.73 g of 5-[4-{(E)-3-(1-methyl-6-indolyl)acryloyl}piperazin-1-yl]-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine.

Provenance & Evidence