Hydrochloric Acid → HCID 67865050, compound

Participants

Reaction Steps

623 mg of methyl {4-[2-(4-chlorophenyl)sulfonylaminoethyl]-2-fluorophenoxyacetylamino}acetate are dissolved in 8 ml of methanol, and 2.8 ml of an aqueous 1N sodium hydroxide solution are added thereto. After the mixture is allowed to stand for 3 hours, the mixture is made acidic with 10% hydrochloric acid, extracted with ethyl acetate, dried and evaporated to remove the solvent. The residue is recrystallized from a mixture of tetrahydrofuran, isoproylether and n-hexane. 560 mg of {4-[2-(4-chlorophenyl)sulfonylaminoethyl]-2-fluorophenoxyacetylamino}acetic acid are obtained as colorless prisms.

Provenance & Evidence