HCID 15714024, compound → HCID 23709819, compound

HRID 1709270Notes

Reaction equation

HRID 1709270 reaction equation
[C:1]1([S:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:23]=[CH:22][C:16]([O:17][CH2:18][C:19]([O-:21])=[O:20])=[C:15]([N+:24]([O-])=O)[CH:14]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+:27]>CO.[C].[Pd]>[C:1]1([S:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:23]=[CH:22][C:16]([O:17][CH2:18][C:19]([O-:21])=[O:20])=[C:15]([NH2:24])[CH:14]=2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[Na+:27]

Participants

4

Reactant 1

HCID 15714024HCID 15714024, compound

Product 1

HCID 23709819HCID 23709819, compoundYield 96.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

2.18 g of sodium 4-(2-benzenesulfonylaminoethyl)-2-nitrophenoxyacetate are dissolved in 50 ml of 80% methanol, and 0.44 g of 10% palladium-carbon is added thereto. After the mixture is subjected to catalytic hydrogenation for 3 hours at room temperature under atmospheric pressure, the catalyst is filtered off. The filtrate is condensed to dryness, and the residue is recrystallized from a mixture of isopropylether and water. 1.94 g of sodium 4-(2-benzenesulfonylaminoethyl)-2-aminophenoxyacetate are obtained as pale yellow scales.

Workup

  1. filtrationthe catalyst is filtered off
  2. customcondensed to dryness
  3. customthe residue is recrystallized from a mixture of isopropylether and water

Sources & evidence

ORD record
ord-de4a1f1cb2be448fa0d30fb82b250ba0
Source dataset
uspto-grants-1990_08
Patent number
US04948810

Reaction notes

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