HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(Benzyloxy)-3,5-difluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,5-Difluoro-4-hydroxybenzaldehyde | HCID 10192584 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(Benzyloxy)-3,5-difluorobenzaldehyde | HCID 15714026 | — |
Reaction Steps
20 g of 4-hydroxy-3,5-difluorobenzaldehyde are dissolved in dimethylsulfoxide, and potassium carbonate and benzyl chloride are added thereto. After the mixture is stirred at room temperature, water is added thereto. The mixture is extracted with ethyl acetate and evaporated to remove the solvent. The residue is purified by silica gel column chromatography to give 17.4 g of 4-benzyloxy-3,5-difluorobenzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04948810 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-7dd0002dc3864c6cb056e52822732410 |
| Source note | uspto-grants-1990_08 |