HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-[2-(4-Chlorophenyl)sulfonylaminopropyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| Reactant | Hydroxyamphetamine Hydrobromide | HCID 9377 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-[2-(4-Chlorophenyl)sulfonylaminopropyl)phenol | HCID 14579375 | 100% |
Reaction Steps
A mixture of 2.32 g of 4-(2-aminopropyl)phenol hydrobromide, 4.2 g of sodium bicarbonate, 50 ml of water, 100 ml of ethyl acetate and 2.11 g of 4-chlorophenylsulfonyl chloride is stirred at room temperature for 3 hours. After the reaction, the ethyl acetate layer is separated therefrom, dried and evaporated to remove the solvent. 3.25 g of 4-[2-(4-chlorophenyl)sulfonylaminopropyl)phenol are obtained as brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04948810 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-fafb6a62e65149fc8710a657836cde31 |
| Source note | uspto-grants-1990_08 |