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Water → N-[2-(4-Methoxyphenyl)propyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 2-(4-Methoxyphenyl)propan-1-amine | HCID 202625 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-[2-(4-Methoxyphenyl)propyl]acetamide | HCID 14579484 | 99.8% |
反応手順
A mixture of 19.8 g of 1-amino-2-(4-methoxyphenyl)propane, 200 ml of ethyl acetate, 200 ml of water and 84 g of sodium bicarbonate is cooled at 5° to 10° C. under stirring, and 18.8 g of acetyl chloride in 100 ml of ethyl acetate are added dropwise thereto at the same temperature. After the reaction, the ethyl acetate layer is separated therefrom, washed, dried and then condensed to dryness under reduced pressure. 24.8 g of 1-acetylamino-2-(4-methoxyphenyl)propane are obtained as oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04948810 |
| 出典データセット | uspto-grants-1990_08 |
| ORD ID | ord-22b1727281c84c45b1f4c781668f8386 |
| 出典メモ | uspto-grants-1990_08 |