2-(Dimethylamino)ethyl acrylate → HCID 23037626, compound

Participants

Reaction Conditions

Reaction Steps

Dimethylaminoethyl acrylate (11.4 mls) was added to a stirred solution of 3-bromomethylbenzophenone (20.6g) in ethyl acetate (100 mls) at 60° C. and the mixture stirred for 1 hour at 60° C. After cooling to room temperature the mixture was stirred for 1 hour prior to filtration. After washing the residue with ethyl acetate (3x) the solid was dried under vacuo at room temperature. The crude title compound was obtained as a cream solid (27.3g, MP 165°-168° C.) which was recrystallised from propan-2-ol/isopropyl ether. Filtration followed by washing with isopropyl ether then drying under vacuo at room temperature gave the title compound as pale cream crystals. (20.2g, yield =64.5%, MP 168°-169° C.).

Provenance & Evidence