Methanol → HCID 13826023, compound

Participants

Reaction Steps

11.4 g. (29.8 mmole) 4-Bromobenzenesulphonic acid(4-acetylphenethylamide) are dissolved in a mixture of 40 ml. methanol and 100 ml. ethanol and 0.85 g. (22.4 mmole) sodium borohydride then added portionwise thereto at 0° C. Subsequently, the reaction mixture is stirred at ambient temperature for 2 hours and then evaporated in a vacuum. After the addition of dilute hydrochloric acid, the reaction mixture is shaken out with methylene chloride and the methylene chloride phase is dried with anhydrous sodium sulphate Thereafter, it is evaporated and the residue is recrystallised from toluene. Yield 10.4 g. (91% of theory): m.p. 125°-127° C.

Provenance & Evidence