Hydrochloric Acid → HCID 70373490, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2.63 g. (16 mmole) octanoyl chloride in 25 ml. methylene chloride is slowly added dropwise at 0° C. to a mixture of 5.5 g. (16 mmole) 4-chlorobenzenesulphonic acid-4-(2-hydroxyethyl)-phenethylamide], 1.8 g. (18 mmole) triethylamine and 100 ml. methylene chloride. The reaction mixture is then maintained for 1 hour at 0° C. and for a further 2 hours at ambient temperature. It is subsequently shaken out with dilute hydrochloric acid and water, dried with anhydrous sodium sulphate and evaporated. After chromatography with silica gel/methylene chloride, there are obtained 3.8 g. (51% of theory) of the desired product: m.p. 55° C.

Provenance & Evidence