Benzothiazole → Benzothiazole

HRID 1709298Notes

Reaction equation

HRID 1709298 reaction equation
C(C1[C:10](=O)[NH:9][C:8]2[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=2[S:6]C1)CC.S1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2N=C1.[C:25]([OH:32])(=[O:31])C=CCCC>>[S:6]1[C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[N:9]=[CH:10]1.[C:19]1([C:25]([OH:32])=[O:31])[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]=1

Participants

5

Reactant 3

HCID 7222BenzothiazoleHCID 144862-Hexenoic acidHCID 144541102,3-Dihydro-3-propyl-1,5-benzothiazepin-4(5H)-one

Product 2

HCID 7222BenzothiazoleHCID 694701-Cyclohexene-1-carboxylic acid

Procedure

In an analogous manner to the previous examples, 2,3-dihydro-3-propyl-1,5-benzothiazepin-4(5H)-one (melting point: 120°-122° C.) was obtained from benzothiazole and 2-hexenic acid, 2,3-dihydro-2,3-tetramethylene-1,5-benzothiazepin-4(5H)-one (melting point: 225°-227° C.) was obtained from benzothiazole and cyclohexene-1-carboxylic acid and 2,3-dihydro-7,8-dimethyl-1,5-benzothiazepin-(5H)one (melting point: 241°-244° C.) was obtained from 5,6-dimethylbenzothiazole and acrylic acid.

Sources & evidence

ORD record
ord-00fca1354b3f47d9832e7e7c0ee4c560
Source dataset
uspto-grants-1990_08
Patent number
US04948886

Reaction notes

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