HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2,4,5-Trifluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2,4,5-Trifluorobenzoic acid | HCID 521170 | — |
| Catalyst | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,4,5-Trifluorobenzoyl chloride | HCID 145164 | — |
Reaction Steps
To a solution of 5.24 g of 2,4,5-trifluorobenzoic acid in 50 ml of ether containing two drops of N,N-dimethylformamide was added, under argon, oxalyl chloride dropwise over 30 minutes. Stirring was continued for an additional 30 minutes when gas evolution ceased. The ether was removed in vacuo and the residue vacuum distilled to give 5.07 g of the desired compound, bp 26°-27° C./0.75 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04948894 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-811da5f3a7a14a8bba62cb2f2b98b4db |
| Source note | uspto-grants-1990_08 |